Analysis of body water compartments in relation to tissue depletion in clinically stable patients with chronic obstructive pulmonary disease.

forrás: http://www.ncbi.nlm.nih.gov/pubmed/8988918


2014-04-09 14:54:40


Tissue depletion often occurs in patients with chronic obstructive pulmonary disease (COPD), even in those that are weight-stable. Limited data are available, however, about changes in body water compartments in chronic wasting diseases such as COPD. The purpose of this study was to measure body composition in severe COPD patients with special attention to fat-free mass (FFM) depletion and the distribution of body water compartments. Total body water (TBW) and extracellular water (ECW) were measured by deuterium and sodium bromide dilution techniques, respectively, in 38 COPD patients (age: 65 +/- 9 y, forced expiratory volume in 1 s: 38 +/- 14% of predicted) in a stable clinical condition. FFM was calculated by assuming a hydration coefficient of 73%. Underweight patients [body mass index (BMI; in kg/m2) < or = 21] were characterized by a significantly lower percentage fat mass than normal-weight patients, but no significant difference was found in the ratio of ECW to intracellular water (ICW)(BMI < or = 21: 0.72 +/- 0.12, BMI > 21: 0.71 +/- 0.16; NS). When the study population was divided into depleted patients (FFM/height2 < or = 15 kg/m2) and nondepleted patients (FFM/height2 > 15 kg/m2), there was no significant difference in the percentage fat mass, but the ECW-ICW ratio was significantly higher in the depleted patients (0.78 +/- 0.16) than in the nondepleted patients (0.66 +/- 0.12, P < 0.05); this was most pronounced in women. In conclusion, it was found that COPD patients with extreme FFM wasting are characterized by an increased ECW-ICW ratio despite a relatively spared fat mass.


A testben található víz rekeszek elemzése a krónikus obstruktív tüdőbetegségben szenvedő klinikailag stabil betegek szövetállomány csökkenésével kapcsolatban

forrás: http://www.ncbi.nlm.nih.gov/pubmed/8988918


2014-04-09 14:54:40


Szövetállomány csökkenés gyakran előfordul krónikus obstruktív tüdőbetegségben (COPD –chronic obstructice pulmonary disease) szenvedő betegeknél, még azoknál is, akiknek a súlyuk stabil. Korlátozott mennyiségű adat áll azonban rendelkezésre a testben található víz rekeszek változásaival kapcsolatban, akik olyan súlyvesztéssel járó betegségben szenvednek, mint, amilyen a COPD. Ennek a tanulmánynak a célja az volt, hogy a súlyos COPD-s betegeknél mérjük a test összetételét, különös tekintettel a zsírmentes tömeg (fat free mass - FFM) csökkenésére és a testben található vízrekeszek eloszlására. A teljes test víztartalmát (total body water - TBW) és a sejten kívüli vízmennyiséget (extracellular water - ECW) deutérium, illetve nátrium bromid hígítási eljárásokkal mértük 38, stabil klinikai állapotú COPD-s betegnél (koruk 65 +/- 9 év, erőltetett légzési térfogat egy másodperc alatt: az előre jelzettnek 38 +/- 14%-a).

Az FFM-t 73%-os hidratáltsági koefficiens feltevésével számítottuk. Azon sovány betegeket, ahol a test tömeg index (body mass index – BMI  kg/m²) kisebb volt, mint 21 vagy  21-el egyenlő volt, jóval kisebb mértékű zsírtömeg jellemezte, mint az átlagos súlyú betegeket, de nem találtunk jelentős eltérést a sejten kívüli víznek (ECW) a sejten belüli vízhez (intracellular water - ICW) viszonyított arányában (BMI< vagy = 21: 0.72 +/- 0.12, BMI >21: 0.71 +/-0.16;  NS). Amikor a vizsgált népességet felosztottuk szövet csökkenéses betegekre (FFM/magasság2 <vagy = 15 kg/m²) és nem szövet csökkenéses betegekre (FFM/magasság2> 15/kg/m²),  nem volt jelentős eltérés a százalékos zsírtömegben, de az ECW-ICW arány jelentős mértékben magasabb volt a szövetállomány csökkenéses betegeknél (0,78 +/- 0,16), mint a nem szövetállomány csökkenéses betegeknél (0,66 +/-0,12, P< 0,05); ez még inkább hangsúlyos volt nők esetében. Következésképpen azt találtuk, hogy azokat a COPD betegeket, akiknél kiugró FFM vesztés jelentkezett, megnövekedett ECW-ICW arány jellemezte aránylag csekély zsírtömeg ellenére.


Analiza diviziunilor apei din corp în relaţie cu degradarea ţesuturilor, la pacienţii stabili clinic cu obstrucţie pulmonară cronică.

forrás: http://www.ncbi.nlm.nih.gov/pubmed/8988918


2014-04-09 14:54:40


Degradarea de ţesut apare adesea la pacienţii bolnavi de obstrucţie pulmonară cronică (COPD), chiar şi la cei care sunt stabili din punct de vedere al greutăţii. Cu toate acestea, sunt disponibile doar informaţii limitate cu privire la schimbările care survin în diviziunile apei din corp, în boli de epuizare cronică precum COPD. Scopul acestui studiu a fost să măsoare compoziţia corpului la pacienţi cu afecţiune CPOD severă, acordând atenţie specială degradării masei fără grăsimi (FFM) şi distribuţiei diviziunilor apei din corp. Apa totală din corp (TBW) şi apa extracelulară (ECW) au fost măsurate prin tehnicile de diluţie a deuteriumului şi respectiv a bromurii de sodiu, la 38 pacienţi COPD (vârsta: 65 +/- 9 ani, volum de expirare forţată într-o secundă: 38 +/- 14% din cel prezis) aflaţi într-o stare stabilă din punct de vedere clinic. FFM a fost calculată prin presupunerea unui coeficient de hidratare de 73%. Pacienţii subponderali [indicele de masă corporală (BMI; în kg/m2) < sau = 21] au prezentat un procent semnificativ scăzut de masă de grăsimi faţă de pacienţii cu greutate normală, dar nu a fost găsită o diferenţă semnificativă în raportul dintre ECW şi apa intracelulară (ICW)(BMI < sau = 21: 0,72 +/- 0,12 , BMI > 21: 0,71 +/- 0,16; NS). Când grupul de studiu a fost împărţit în pacienţi cu epuizare (FFM/înălţime2 < sau = 15 kg/m2) şi pacienţi fără epuizare (FFM/înălţime2 > 15 kg/m2), nu au existat diferenţe semnificative în procentul de masă de grăsimi, dar raportul ECW-ICW  a fost semnificativ mai mare în pacienţii cu epuizare (0,78 +/- 0,16) faţă de pacienţii fără epuizare (0,66 +/- 0,12 , P < 0,05); acesta a fost cel mai pronunţat la femei. În concluzie, s-a descoperit că pacienţii COPD cu epuizare extremă FFM sunt caracterizaţi de un raport mărit ECW-ICW în ciuda unei mase relative de grăsime economisită.


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