Beta-glucans in higher fungi and their health effects.

forr√°s: http://www.ncbi.nlm.nih.gov/pubmed/19906249


2015-02-17 14:44:05


Together with chitin, the beta-glucans are components of mycetes' cell walls. A high level of biological efficiency has been found in beta-glucans, especially beta-1,3-D-glucans and beta-1,6-D-glucans isolated from some basidiomycetes. (Biological efficiency refers to the relative ability of beta-glucans to promote a desired response, for example to induce leukocyte activation and to produce inflammatory mediators.) These polysaccharides increase the number of Th1 lymphocytes, which help protect organisms against allergic reactions. A number of beta-glucans, for example pleuran from Oyster (Pleurotus spp.) mushrooms or lentinan from Shiitake (Lentinus edodes) mushrooms, have shown marked anticarcinogenic activity. In addition to having an immunity-stimulating effect, beta-glucans may participate in physiological processes related to the metabolism of fats in the human body. Their application results in a decrease in the total cholesterol content in blood and may also contribute to reductions in body weight.


Polysaccharides from Tricholoma matsutake and Lentinus edodes enhance 5-fluorouracil-mediated H22 cell growth inhibition.

forr√°s: http://www.ncbi.nlm.nih.gov/pubmed/24992758


2015-02-17 14:39:32


OBJECTIVE:

Few studies have investigated the effects produced by combinations of polysaccharides and chemotherapeutic drugs in cancer treatment. We hypothesized that a combination of polysaccharides (COP) from Lentinus edodes and Tricholoma matsutake would improve the efficacy of 5-fluorouracil (5-FU)-mediated inhibition of H22 cell growth.

METHODS:

Mice were injected H22 cells and then treated with either 5-FU, polysaccharides from Tricholoma matsutake (PTM), polysaccharides from Lentinus edodes (PL), PTM+PL, 5-FU+PTM, 5-FU+ PL, or 5-FU + COP. The tumor weight and volume, and splenic CD4 + and CD8 + T cell frequencies, were determined. Additionally, splenic natural killer (NK) cell and cytotoxic T lymphocyte (CTL) activities were assessed and the serum levels of tumor necrosis factor-alpha (TNF-alpha), Interleukin-2 (IL-2), and Interferon-gamma (IFN-gamma) were measured.

RESULTS:

Compared with mice from the control, 5-FU, PL, PTM, PTM + PL, 5-FU + PL, and 5-FU + PTM groups, mice treated with 5-FU + COP showed: (a) significantly reduced tumor weight and volume (P < 0.05); (b) significantly higher serum levels of TNF-alpha, IL-2, and IFN-gamma (P < 0.05); (c) significantly increased CD4+ and CD8+ T cell frequencies in the spleen (P < 0.05); and (d) significantly increased splenic NK cell and CTL activities (P < 0.05). The tumor weight and volume in mice treated with 5-FU+PL or 5-FU+PTM were significantly reduced compared with mice treated with 5-FU alone (P < 0.05). Serum levels of TNF-alpha, IL-2, and IFN-gamma, frequencies of CD4 + and CD8+ T cells in the spleen, and splenic NK and CTL activities were also significantly increased in mice treated with 5-FU+PL or 5-FU+PTM compared with mice treated with 5-FU alone (P < 0.05).

CONCLUSION:

Polysaccharides from Lentinus edodes and Tricholoma matsutake could enhance the efficacy of 5-FU-mediated H22 cell growth inhibition.

 


B√©ta-gl√ľk√°nok (term√©szetben is elŇĎfordul√≥ poliszaccharidok) a baz√≠diumos gomb√°kban (magasabb rendŇĪ gomb√°k) √©s eg√©szs√©g√ľgyi hat√°saik

forr√°s: http://www.ncbi.nlm.nih.gov/pubmed/19906249


2015-02-17 14:44:05


Rop O.1, Mlcek J., Jurikova T.

1Department of Food Engineering, Faculty of Technology, Tomas Bata University in Zlin 762 72 Zlin, Czech Republic [√Člelmiszeripari Tansz√©k, MŇĪszaki Kar, Tomas Bata Egyetem, Zlin Cseh K√∂zt√°rsas√°g] rop@ft.utb.cz

A kitinnel egy√ľtt a b√©ta-gl√ľk√°nok a gomb√°k sejtfal√°nak alkot√≥elemei. A biol√≥giai hat√©konys√°g magas fok√°t tal√°lt√°k a b√©ta-gl√ľk√°nokban, k√ľl√∂n√∂sen a b√©ta-1,3-D-gl√ľk√°nokban √©s a b√©ta-1,6-D-gl√ľk√°nokban, amelyet n√©h√°ny baz√≠diumos gomb√°b√≥l k√ľl√∂n√≠tettek el. (A biol√≥giai hat√©konys√°g a b√©ta-gl√ľk√°noknak arra a viszonylagos k√©pess√©g√©re vonatkozik, hogy egy k√≠v√°nt v√°laszt v√°ltsanak ki, p√©ld√°ul hogy elŇĎid√©zz√©k a leukocit√°k aktiv√°l√≥d√°s√°t √©s gyullad√°s k√∂zvet√≠tŇĎket √°ll√≠tsanak elŇĎ.) Ezek a poliszaccharidok n√∂velik a Th1 limfocit√°k sz√°m√°t, amelyek v√©dik a szervezeteket az allergi√°s reakci√≥kkal szemben. Sz√°mos b√©ta-gl√ľk√°n, p√©ld√°ul a pleuran a laskagomb√°b√≥l (Pleurotus spp.) vagy a lentinan a Shiitake gomb√°b√≥l (Lentinus edodes) hat√°rozott r√°kellenes hat√°st mutat. Mivel immunstimilul√°l√≥ hat√°ssal rendelkeznek, a b√©ta-gl√ľk√°nok r√©szt vehetnek olyan fiziol√≥giai folyamatokban, amelyek az emberi testben a zs√≠ranyagcser√©vel kapcsolatosak. Alkalmaz√°suk eredm√©nyek√©ppen cs√∂kken a teljes koleszterintartalom a v√©rben √©s hozz√°j√°rulhatnak a tests√ļly cs√∂kken√©s√©hez is.


A tricholoma matsutake-bŇĎl [foltost√∂nkŇĪ gyŇĪrŇĪspereszke, fenyŇĎgomba] √©s a Lentinus edodes-bŇĎl [shiitake gomba] sz√°rmaz√≥ poliszaccharidok n√∂velik az 5-fluorouracil k√∂zvet√≠tette H22 [hepatocarcinoma] sejt n√∂veked√©s g√°tl√°st

forr√°s: http://www.ncbi.nlm.nih.gov/pubmed/24992758


2015-02-17 14:39:32


Ren M., Ye L., Hao X., Ren Z., Xu K., Li J.

C√ČL: Kev√©s kutat√°s vizsg√°lta a poliszaccharidok √©s a kemoter√°pi√°s k√©sz√≠tm√©nyek kombin√°ci√≥ja √°ltal elŇĎid√©zett hat√°sokat a r√°kkezel√©sben. Felt√©telezt√ľk, hogy a shiitake- √©s fenyŇĎ gomb√°b√≥l sz√°rmaz√≥ poliszaccharidok kombin√°ci√≥ja (COP ‚Äď combination of polysaccharides) jav√≠thatja az 5-Fluorouracil (5-FU ‚Äď citotoxikus r√°kellenes kemoter√°pi√°s gy√≥gyszer) k√∂zvet√≠tette H22 sejtn√∂veked√©s g√°tl√°st.

ELJ√ĀR√ĀSOK: Egerekbe H22 sejteket fecskendezt√ľnk √©s azut√°n vagy 5-FU-val, vagy a Tricholoma matsutakebŇĎl (PTM) vagy a Lentinus edodesbŇĎl sz√°rmaz√≥ poliszaccharidokkal (PL) is kezelt√ľk ŇĎket a k√∂vetkezŇĎk szerint: PTM + PL, 5-FU+ PTM, 5-FU + PL vagy 5-FU + COP. Meghat√°roz√°sra ker√ľlt a daganat s√ļlya √©s t√©rfogata, valamint a l√©p CD4+ √©s CD8+ T sejtek gyakoris√°ga.

√Črt√©kelt√ľk a l√©p term√©szetes √∂lŇĎsejtjeinek (NK ‚Äď natural killer) √©s a citotoxikus T limfocit√°nak (CTL - cytotoxic T lymphocyte) aktivit√°sait, valamint a tumor nekr√≥zis faktor alf√°t (TNF-alpha). M√©rt√ľk az Interleukin-2-t (IL-2) √©s az Interferon-gamm√°t (IFN-gamma).

 

EREDM√ČNYEK: √∂sszehasonl√≠tva a kontrollb√≥l sz√°rmaz√≥, az 5-FU, a PL, a PTM, a PTM + PL, az 5 FU + PL √©s az 5-FU + PTM egerek csoportjaival, az 5-FU + COP-val kezelt egerek a k√∂vetkezŇĎket mutatt√°k:

(a) jelentŇĎsen cs√∂kkent a daganat s√ļlya √©s t√©rfogata (P <0,05);

(b) a TNF-alpha, az IL-2 √©s az IFN-gamma sz√©rum szintjei jelentŇĎsen magasabbak voltak (P <0,05);

(c) jelentŇĎsen megn√∂vekedtek a CD4+ √©s CD8+ T sejt gyakoris√°gok a l√©pben (P <0,05) √©s

(d) jelentŇĎsen megn√∂vekedett l√©p NK sejt √©s CTL aktivit√°sok (P <0,05).

√Ėsszehasonl√≠tva a csak 5-FU-val kezelt egerek√©vel, az 5-FU + PL-lel √©s az 5-FU + PTM-el kezelt egerekben a tumor s√ļlya √©s t√©rfogata jelentŇĎsen cs√∂kkent (P <0,05). A TNF-alpha, az IL-2 √©s az IFN-gamma sz√©rum szintjei, a CD4+ √©s a CD8+ T sejtek gyakoris√°ga a l√©pben √©s a l√©p NK √©s CTL aktivit√°sai szint√©n jelentŇĎs m√©rt√©kben n√∂vekedtek az 5-FU + PL-lel vagy az 5-FU + PTM-mel kezelt egerekben a csak 5-FU-val kezelt egerek√©hez k√©pest (P <0,05).

K√ĖVETKEZTET√ČS: A Lentinus edodesbŇĎl √©s a Tricholoma matsutake-bŇĎl sz√°rmaz√≥ poliszaccharidok n√∂velhetik az 5-FU k√∂zvet√≠tette H22 sejtn√∂veked√©s g√°tl√°s hat√©konys√°g√°t.


QR-CODE

Download image: Right click, "Image save as..."