forrás: http://medpublics.com/docs/OlimpiqSXC_Retinal.pdf
2021-06-23 10:37:34
Aim: To determine whether treatment with the stem cell stimulator Olimpiq® Stem×Cell prevents increase of retinal and renal vascular permeability in alloxan-induced diabetic rats. Materials and Methods: Two groups of Wistar rats were made diabetic by single intraperitoneal injection of Alloxan. The third, the control group, received vehicle alone. One diabetic group received Olimpiq® Stem×Cell treatment for 4 weeks. The permeability of the blood–retinal barrier (BRB) and renal vessels were measured by the extravasation of fluorescein–labeled bovine serum albumin. Results: Six weeks subsequently to Alloxan injection, significantly elevated the tissue fluorescence, the renal vascular leakage and BRB breakdown was demonstrated in the diabetic group, compared to the nondiabetic group. Olimpiq® Stem×Cell treatment significantly reduced the BRB breakdown, tissue fluorescence, and vascular leakage. Conclusion: Olimpiq® Stem×Cell would be a useful choice of treatment for complications associated with increased vascular permeability of diabetes, such as retinopathy or nephropathy.
forrás: https://pubmed.ncbi.nlm.nih.gov/32125455/
2021-01-22 11:19:04
Josef Penninger is the founder and a shareholder of Apeiron, the company that makes rhACE2. Arthur Slutsky has been a paid consultant for Apeiron. No other conflicts of interested have been reported.
forrás: http://medpublics.com/docs/computational_screening.pdf
2021-01-21 14:14:58
In the current spread of novel coronavirus (SARS-CoV-2), antiviral drug discovery is of great importance. AutoDock Vina was used to screen potential drugs by molecular docking with the structural protein and non-structural protein sites of new coronavirus. Ribavirin, a common antiviral drug, remdesivir, chloroquine and luteolin were studied. Honeysuckle is generally believed to have antiviral effects in traditional Chinese medicine. In this study, luteolin (the main flavonoid in honeysuckle) was found to bind with a high affinity to the same sites of the main protease of SARS-CoV-2 as the control molecule. Chloroquine has been proved clinically effective and can bind to the main protease; this may be the antiviral mechanism of this drug. The study was restricted to molecular docking without validation by molecular dynamics simulations. Interactions with the main protease may play a key role in fighting against viruses. Luteolin is a potential antiviral molecule worthy of attention
forrás: http://www.ncbi.nlm.nih.gov/pubmed/8988918
2014-04-09 14:54:40
Tissue depletion often occurs in patients with chronic obstructive pulmonary disease (COPD), even in those that are weight-stable. Limited data are available, however, about changes in body water compartments in chronic wasting diseases such as COPD. The purpose of this study was to measure body composition in severe COPD patients with special attention to fat-free mass (FFM) depletion and the distribution of body water compartments. Total body water (TBW) and extracellular water (ECW) were measured by deuterium and sodium bromide dilution techniques, respectively, in 38 COPD patients (age: 65 +/- 9 y, forced expiratory volume in 1 s: 38 +/- 14% of predicted) in a stable clinical condition. FFM was calculated by assuming a hydration coefficient of 73%. Underweight patients [body mass index (BMI; in kg/m2) < or = 21] were characterized by a significantly lower percentage fat mass than normal-weight patients, but no significant difference was found in the ratio of ECW to intracellular water (ICW)(BMI < or = 21: 0.72 +/- 0.12, BMI > 21: 0.71 +/- 0.16; NS). When the study population was divided into depleted patients (FFM/height2 < or = 15 kg/m2) and nondepleted patients (FFM/height2 > 15 kg/m2), there was no significant difference in the percentage fat mass, but the ECW-ICW ratio was significantly higher in the depleted patients (0.78 +/- 0.16) than in the nondepleted patients (0.66 +/- 0.12, P < 0.05); this was most pronounced in women. In conclusion, it was found that COPD patients with extreme FFM wasting are characterized by an increased ECW-ICW ratio despite a relatively spared fat mass.
forrás: https://medpublics.com/docs/gyulladas_es
2022-05-04 12:19:43
A gyulladás és a tumorgenezis közötti kapcsolat jól ismert, és az elmúlt évtizedben ezt számos, genetikai, farmakológiai és epidemiológiai adatokból származó bizonyíték támasztotta alá. A gyulladásos bélbetegség a vastagbélrák kialakulásának egyik fontos kockázati tényezője. A gyulladás valószínűleg a sporadikus és az öröklődő vastagbélrák más formáiban is szerepet játszik. Azok a molekuláris mechanizmusok, amelyek révén a gyulladás elősegíti a rák kialakulását, még feltáratlanok, és eltérőek lehetnek a vastagbélráknak a vastagbélgyulladással összefüggő, és más formái között. A közelmúltban végzett munkák megvilágították a különböző immunsejtek, citokinek és más immunmediátorok szerepét a vastagbél tumorgenezisének gyakorlatilag minden szakaszában, beleértve a tumorok kialakulását, promócióját, progresszióját és metasztázisát. Ez az áttekintés ezeket a mechanizmusokat, valamint a megelőzés és a terápia új megközelítéseit tárgyalja.
Magyar nyelven: http://medpublics.com/docs/gyulladas_es_magyar.pdf
