forrás: http://medpublics.com/docs/OlimpiqSXC_Retinal.pdf
2021-06-23 10:37:34
Aim: To determine whether treatment with the stem cell stimulator Olimpiq® Stem×Cell prevents increase of retinal and renal vascular permeability in alloxan-induced diabetic rats. Materials and Methods: Two groups of Wistar rats were made diabetic by single intraperitoneal injection of Alloxan. The third, the control group, received vehicle alone. One diabetic group received Olimpiq® Stem×Cell treatment for 4 weeks. The permeability of the blood–retinal barrier (BRB) and renal vessels were measured by the extravasation of fluorescein–labeled bovine serum albumin. Results: Six weeks subsequently to Alloxan injection, significantly elevated the tissue fluorescence, the renal vascular leakage and BRB breakdown was demonstrated in the diabetic group, compared to the nondiabetic group. Olimpiq® Stem×Cell treatment significantly reduced the BRB breakdown, tissue fluorescence, and vascular leakage. Conclusion: Olimpiq® Stem×Cell would be a useful choice of treatment for complications associated with increased vascular permeability of diabetes, such as retinopathy or nephropathy.
forrás: http://medpublics.com/docs/OlimpiqSXC_Enhancement.pdf
2021-06-22 15:22:30
ABSTRACT Adult stem cells play an important role in the regeneration of damaged organs. Attempts have already been made to enhance stem cell production by cytokines, in order to increase the improvement of cardiac functions after myocardial infarction. In our present study we investigated the possibility whether instead of cytokine injection dietary stimulation of stem cell production accelerates the organ regeneration in animals. A dietary supplement, Olimpiq StemXCell (Crystal Institute Ltd., Eger, Hungary), containing plant extracts (previously proved to increase the number of circulating CD34þ cells) was consumed in human equivalent doses by the experimental animals. In the first experiment carbon tetrachloride was applied to CBA=Ca mice, to induce liver damage, and liver weights between StemXCell-fed and control animals were compared 10 days after the treatment. In the second model experimental diabetes was induced in F344 rats by alloxan. Blood sugar levels were measured for 5 weeks in the control and StemXCell-fed groups. The third part of the study investigated the effect of StemXCell on cardiac functions. Eight weeks after causing a myocardial infarction in Wistar rats by isoproterenol, left ventricular ejection fraction was determined as a functional parameter of myocardial regeneration. In all three animal models StemXCell consumption statistically significantly improved the organ regeneration (relative liver weights, 4.78 0.06 g=100 g vs. 4.97 0.07 g=100 g; blood sugar levels at week 5, 16 1.30 mmol=L vs. 10.2 0.92 mmol=L; ejection fraction, 57.5 2.23 vs. 68.2 4.94; controls vs. treated animals, respectively). Our study confirms the hypothesis that dietary enhancement of stem cell production may protect against organ injuries and helps in the regeneration.
forrás: https://www.spandidos-publications.com/ijmm/46/1/17
2021-01-22 09:50:43
In view of the emerging COVID‑19 pandemic caused by SARS‑CoV‑2 virus, the search for potential protective and therapeutic antiviral strategies is of particular and urgent interest. Zinc is known to modulate antiviral and antibacterial immunity and regulate inflammatory response. Despite the lack of clinical data, certain indications suggest that modulation of zinc status may be beneficial in COVID‑19. In vitro experiments demonstrate that Zn2+ possesses antiviral activity through inhibition of SARS‑CoV RNA polymerase. This effect may underlie therapeutic efficiency of chloroquine known to act as zinc ionophore. Indirect evidence also indicates that Zn2+ may decrease the activity of angiotensin‑converting enzyme 2 (ACE2), known to be the receptor for SARS‑CoV‑2. Improved antiviral immunity by zinc may also occur through up‑regulation of interferon α production and increasing its antiviral activity. Zinc possesses anti‑inflammatory activity by inhibiting NF‑κB signaling and modulation of regulatory T‑cell functions that may limit the cytokine storm in COVID‑19. Improved Zn status may also reduce the risk of bacterial co‑infection by improving mucociliary clearance and barrier function of the respiratory epithelium, as well as direct antibacterial effects against S. pneumoniae. Zinc status is also tightly associated with risk factors for severe COVID‑19 including ageing, immune deficiency, obesity, diabetes, and atherosclerosis, since these are known risk groups for zinc deficiency. Therefore, Zn may possess protective effect as preventive and adjuvant therapy of COVID‑19 through reducing inflammation, improvement of mucociliary clearance, prevention of ventilator‑induced lung injury, modulation of antiviral and antibacterial immunity. However, further clinical and experimental studies are required.
forrás: http://www.ncbi.nlm.nih.gov/pubmed/23557365
2014-02-18 10:03:26
Ganoderma lucidum (Lingzhi or Reishi) is known as a bitter mushroom with remarkable health benefits. The active constituents found in mushrooms include polysaccharides, dietary fibers, oligosaccharides, triterpenoids, peptides and proteins, alcohols and phenols, mineral elements (such as zinc, copper, iodine, selenium, and iron), vitamins, and amino acids. The bioactive components found in the G. lucidum mushroom have numerous health properties to treat diseased conditions such as hepatopathy, chronic hepatitis, nephritis, hypertension, hyperlipemia, arthritis, neurasthenia, insomnia, bronchitis, asthma, gastric ulcers, atherosclerosis, leukopenia, diabetes, anorexia, and cancer. In spite of the voluminous literature available, G. lucidum is used mostly as an immune enhancer and a health supplement, not therapeutically. This review discusses the therapeutic potential of G. luidum to attract the scientific community to consider its therapeutic application where it can be worth pursuing.
forrás: http://www.ncbi.nlm.nih.gov/pubmed/24578648
2015-02-19 14:47:39
Ristic-Medic D.1, Perunicic-Pekovic g.2, Rasic-Milutinovic Z.3, Takic M.1, Popovic T.1, Arsic A.1, Glibetic. M1
1Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade
[a Belgrádi Egyetem Orvostudományi Intézete, Táplálkozástudományi és Anyagcsere Kutatási Központ]
2Department of Nephrology and Dyalisis, Clinical Hospital Zemun, University of Belgrade [Vesegyógyászati és Dialízis Osztály, Klinikai Kórház, Zimony, Belgrádi Egyetem]
3Department of Endocrinology, Diabetes and Metabolism, Clinical Hospital Zemun, University of Belgrade
[Endokrinológiai-, Cukorbetegségi- és Anyagcsere Osztály, Klinikai Kórház, Zimony, Belgrádi Egyetem]
Kivonat
HÁTTÉR: A növényi magvak felkeltették az érdeklődést zsírsav tartalmuk miatti jótékony egészségügyi hatásuknak köszönhetően. Ennek a kutatásnak a célja az, hogy meghatározza az őrölt szezám/tök/len mag keverék étrendi fogyasztásának hatásait a glikémiás szabályozásra, a szérum zsírokra, a foszfolipid zsírsav állapotra és hemodialízises kezelés alatt álló betegeknél a gyulladási tényezőkre.
ELJÁRÁSOK: Jó táplálkozási státuszú harminc beteget (18 férfit és 12 nőt) vontunk be a kutatásba. A résztvevők 30 g őrölt szezám/tök/len (6g/6g/18g) mag keveréket fogyasztottak szokásos étrendjükhöz hozzáadva.
EREDMÉNYEK: A teljes n-6 és n-3 többszörösen telítetlen zsírsavak és a linolén-, a dihomo-gamma-linolén (DGLA)- az arachidon-, az alpha-linolén (ALA)-, az eicosapentaén- a docosapentaén- és a docosahexaén (DHA) sav szintek 12 hetes táplálék kiegészítés után megemelkedtek. A szérum triglicerid szint (P <0,001), a glukóz, az inzulin, a számított IR HOMA1 (P <0,05), és a gyulladás jelzőinek (TNF-alpha2, IL-63 és a hs-CRP4, P <0 001) jelentős mértékű csökkenése volt megfigyelhető a magkezelést követően. A CRP és a TNF-alpha fordítottan korrelált az ALA-val [alfa-linolénsav], a DHA-val [docohexaénsav] és a DGLA-val [dihomo-y-linolénsav].
KÖVETKEZTETÉS: Ennek a kutatásnak az eredményei azt jelezték, hogy a szokásos étrendhez hozzáadott étkezési őrölt szezám/tök/len mag keverék csökkentette a triglicerid, a CRP, a TNF-alfa és az IL-6 szinteket, befolyással volt a glikémiás szabályozásra és javította a zsírsav profilt, valamint a bőrviszketegség tüneteit hemodialízises betegeknél.
1 Insulin Resistance Homeostatic Model Assesment – inzulin rezisztencia homeosztatikus modell értékelése
2 TNF-alpha: tumor necrosis factor Alpha – daganat elhalási alfa faktor
3 Interleukin-6
4 high-sensivity C-reactive Protein - nagy érzékenységű C-reaktív fehérje
